{"id":4098,"date":"2026-11-02T16:36:13","date_gmt":"2026-11-02T08:36:13","guid":{"rendered":"https:\/\/mydocsay.com\/?p=4098"},"modified":"2026-11-02T16:36:16","modified_gmt":"2026-11-02T08:36:16","slug":"allergy_and_gene","status":"publish","type":"post","link":"https:\/\/mydocsay.com\/en\/allergy_and_gene\/","title":{"rendered":"Allergies are hereditary! Is there no cure? Is that really true?"},"content":{"rendered":"<p class=\"has-medium-font-size wp-block-paragraph\">\u4f60\u662f\u4e0d\u662f\u4e5f\u5e38\u807d\u5230\u9019\u53e5\u8a71\uff1f\u2500\u300c\u904e\u654f\u5c31\u662f\u907a\u50b3\u4f86\u7684\u5566\uff01\u9019\u8f29\u5b50\u5c31\u662f\u9019\u6a23\uff0c\u7a69\u5b9a\u5403\u85e5\uff0c\u904e\u654f\u4e0d\u6703\u597d\u7684\u3002\u300d<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u4e0d\u53ea\u662f\u4f60\uff0cDr. L \u5c0f\u6642\u5019\u4e5f\u662f\u807d\u9019\u53e5\u8a71\u9577\u5927\u7684\u3002\u6211\u770b\u4e86\u4e2d\u91ab\u3001\u897f\u91ab\uff0c\u8a66\u904d\u5404\u7a2e\u6c11\u9593\u504f\u65b9\uff0c\u7684\u78ba\uff0c\u904e\u654f\u75c7\u72c0\u5728\u90a3\u6642\u5e7e\u4e4e\u6c92\u6709\u592a\u5927\u7684\u6539\u5584\uff0c\u6211\u4e5f\u5dee\u9ede\u8a8d\u70ba\u9019\u8f29\u5b50\u5c31\u662f\u9019\u6a23\u4e86\uff0c\u76f4\u5230\u6211\u5927\u5b78\u7562\u696d\u70ba\u6b62 \u2500\u2500 \u56e0\u70ba\u6211\u75ca\u7652\u4e86\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u7576\u6642\uff0c\u6709\u4e00\u500b\u91ab\u5b78\u540d\u8a5e\u975e\u5e38\u5ee3\u70ba\u4eba\u77e5\uff1a\u7570\u4f4d\u6027\u76ae\u819a\u708e\uff0c\u610f\u601d\u662f\u8207\u907a\u50b3\u9ad8\u5ea6\u76f8\u95dc\u7684\u6fd5\u75b9\uff0c\u901a\u5e38\u8a00\u5916\u4e4b\u97f3\u5c31\u662f\u300c\u9019\u907a\u50b3\u4f86\u7684\u75be\u75c5\u6703\u8ddf\u8457\u4e00\u8f29\u5b50\u3002\u300d\uff1b\u4f46\uff0c Dr. L \u6700\u7d42\u662f\u75ca\u7652\u4e86\uff0c\u90a3\u9ebc\u662f\u5426\u5c31\u4ee3\u8868\u904e\u53bb\u6211\u5011\u6240\u8a8d\u77e5\u7684 &#8220;\u904e\u654f\u907a\u50b3\u547d\u5b9a\u8ad6&#8221; \uff0c\u4e5f\u61c9\u8a72\u8981\u6709\u6240\u8abf\u6574\u4e86\uff1f\u800c\u9019\u6b21\u60f3\u8207\u5927\u5bb6\u5206\u4eab\u7684\u8ad6\u6587\uff0c\u4fbf\u70ba\u9019\u500b\u6982\u5ff5\u63d0\u4f9b\u4e86\u5f88\u597d\u7684\u79d1\u5b78\u4f50\u8b49\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u65bc2025\u5e74\uff0c\u767c\u8868\u65bc\u5728\u570b\u969b\u91cd\u91cf\u7d1a\u5b78\u8853\u671f\u520a <strong><em>Journal of Allergy and Clinical Immunology<\/em><\/strong> of<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0091674925003276#sec4\" target=\"_blank\" rel=\"noopener\">paper<\/a>\uff1a\u300a Update on the genetics of allergic diseases \u300b\uff0c\u63a2\u8a0e\u4e86\u904e\u654f\u6027\u75be\u75c5\u907a\u50b3\u75c5\u56e0\u5b78\u7684\u6700\u65b0\u7814\u7a76\u9032\u5c55\uff0c\u6db5\u84cb\u904e\u654f\u654f\u611f\u5316\u4ee5\u53ca\u4e94\u7a2e\u4e3b\u8981\u904e\u654f\u6027\u75be\u75c5\u3002\u4ee5\u4e0b Dr. L \u5c07\u91cd\u9ede\u9010\u4e00\u5217\u51fa\uff1a<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"has-luminous-vivid-orange-color has-text-color has-link-color has-medium-font-size wp-elements-1 wp-block-paragraph\">\u258c<strong>\u3010 \u904e\u654f \u3011\u7684 &#8220;\u907a\u50b3\u8ca2\u737b\u5ea6 &#8220;<\/strong><\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">1. \u904e\u654f\u654f\u611f\u5316\uff08AS\uff09\u3001\u7570\u4f4d\u6027\u76ae\u819a\u708e\uff08AD\uff09\u3001\u6c23\u5598\uff08asthma\uff09\u3001\u904e\u654f\u6027\u9f3b\u708e\uff08AR\uff09\u3001\u98df\u7269\u904e\u654f\uff08FA\uff09\u53ca\u55dc\u9178\u6027\u6027\u98df\u9053\u708e\uff08EoE\uff09\u7b49\u904e\u654f\u6027\u75be\u75c5\uff0c\u5177\u6709\u986f\u8457\u7684\u907a\u50b3\u57fa\u790e\uff0c<strong>\u907a\u50b3\u8ca2\u737b\u5ea6\u4ecb\u65bc 30% \u81f3 80% \u4e4b\u9593<\/strong>.<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">2. <strong>\u5e38\u898b\u8b8a\u7570\uff1a<\/strong> \u591a\u6578\u904e\u654f\u75be\u75c5\u662f\u7531\u5177\u8f15\u81f3\u4e2d\u5ea6\u6548\u61c9\u7684\u907a\u50b3\u8b8a\u7570\u8207\u74b0\u5883\u56e0\u5b50\u5171\u540c\u4f5c\u7528\u6240\u81f4\u3002<br>(\u50c5\u6709\u5c11\u6578\u7f55\u898b\u57fa\u56e0\u8b8a\u7570\u624d\u6709\u8f03\u5927\u7684\u904e\u654f\u75be\u75c5\u98a8\u96aa\u5f71\u97ff\u6027)<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">3. \u591a\u6578\u904e\u654f\u98a8\u96aa\u8b8a\u7570\u4f4d\u65bc<strong>\u57fa\u56e0\u9ad4 &#8220;\u975e\u7de8\u78bc\u5340&#8221; <\/strong>\uff0c\u900f\u904e\u8abf\u63a7\u57fa\u56e0\u8868\u73fe\u767c\u63ee\u4f5c\u7528\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">4. \u5e7e\u4e4e\u6bcf\u4e00\u689d\u67d3\u8272\u9ad4\u4e0a\u90fd\u6709\u8207\u904e\u654f\u76f8\u95dc\u7684\u98a8\u96aa\u57fa\u56e0\uff0c\u4e14<strong>\u8a31\u591a\u904e\u654f\u75be\u75c5\u5728\u76f8\u540c\u7684\u57fa\u56e0\u4f4d\u7f6e\u90fd\u6709\u98a8\u96aa\u9ede<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"has-luminous-vivid-orange-color has-text-color has-link-color has-medium-font-size wp-elements-2 wp-block-paragraph\">\u258c<strong>\u3010 \u904e\u654f \u3011\u5404\u7a2e\u8868\u73fe\u578b\u7684\u57fa\u56e0\u76f8\u95dc\u767c\u73fe<\/strong><\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">1. <strong>\u6c23\u5598\uff08Asthma\uff09\uff1a<\/strong> <br>\u5df2\u8b58\u5225 759 \u500b\u98a8\u96aa\u57fa\u56e0\u5ea7\u3002\u57fa\u56e0\u5ea7\u7de8\u78bc\u7d30\u80de\u6fc0\u7d20\u53cd\u61c9\u3001\u7b2c\u4e8c\u578b\u514d\u75ab\u8abf\u7bc0\u53ca\u6297\u539f\u5448\u73fe\u7b49\u76f8\u95dc\u57fa\u56e0\uff08\u5982 <em>TSLP<\/em>,<em>IL4<\/em>,<em>IL13<\/em> \u7b49\uff0c\u4fc3\u6210\u4e86\u76f8\u95dc\u751f\u7269\u88fd\u5291\u7684\u958b\u767c\uff09\u3002\u5152\u7ae5\u671f\u767c\u75c5\u8207\u6210\u4eba\u671f\u767c\u75c5\u7684\u6c23\u5598\u90e8\u5206\u57fa\u56e0\u98a8\u96aa\u4e0d\u540c\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">2. <strong>\u904e\u654f\u654f\u611f\u5316\uff08Allergic sensitization\uff09<\/strong>: <br>\u5df2\u8b58\u5225 212 \u500b\u7368\u7acb\u98a8\u96aa\u57fa\u56e0\u5ea7\u3002\u591a\u6578\u57fa\u56e0\u986f\u8457\u805a\u96c6\u65bc\u89d2\u8cea\u5316\u3001\u767d\u8840\u7403\u6d3b\u5316\u53ca\u514d\u75ab\u7cfb\u7d71\u8abf\u7bc0\u9014\u5f91\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">3. <strong>\u904e\u654f\u6027\u9f3b\u708e\uff08Allergic Rhinitis\uff09\uff1a<\/strong> <br>\u5df2\u8b58\u5225 165 \u500b\u7368\u7acb\u98a8\u96aa\u57fa\u56e0\u5ea7\u3002\u591a\u6578\u8207\u9069\u61c9\u6027\u514d\u75ab\u53cd\u61c9\u3001\u767c\u708e\u4fe1\u865f\u53ca\u6297\u539f\u5448\u73fe\u4f5c\u7528\u6709\u95dc\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">4. <strong>\u7570\u4f4d\u6027\u76ae\u819a\u708e\uff08Atopic Dermatitis\uff09<\/strong>: <br>\u5df2\u8b58\u5225 156 \u500b\u7368\u7acb\u98a8\u96aa\u57fa\u56e0\u5ea7\u3002\u591a\u6578\u53c3\u8207\u767c\u708e\u4fe1\u865f\u50b3\u905e\u3001\u76ae\u819a\u5c4f\u969c\u5b8c\u6574\u6027\u3001\u53ca\u6297\u539f\u5448\u73fe\u4f5c\u7528\uff0c\u4e26\u986f\u8457\u805a\u96c6\u65bc CD4<sup>+<\/sup> T \u7d30\u80de\u6d3b\u5316\u9014\u5f91\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">5. <strong>\u98df\u7269\u904e\u654f\uff08Food Allergy\uff09\uff1a<\/strong> <br>\u5df2\u8b58\u5225 8 \u500b\u7368\u7acb\u98a8\u96aa\u57fa\u56e0\u5ea7\u3002\u591a\u6578\u8207\u6297\u539f\u5448\u73fe\u3001\u86cb\u767d\u9176\u6d3b\u6027\u76f8\u95dc\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">6. <strong>\u55dc\u9178\u6027\u6027\u98df\u9053\u708e\uff08Eosinophilic Esophagitis\uff09\uff1a<\/strong> <br>\u5df2\u8b58\u5225 7 \u500b\u7368\u7acb\u98a8\u96aa\u57fa\u56e0\u5ea7\u3002(\u4f46\u76db\u884c\u7387\u8f03\u4f4e\uff0c\u75c5\u4f8b\u6578\u8f03\u5c11)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u7531\u9019\u7bc7\u7814\u7a76\u8ad6\u6587\u7684\u6578\u64da\uff0cDr. L \u6709\u4e00\u4e9b\u60f3\u6cd5\u60f3\u63d0\u9192\u5927\u5bb6\uff1a<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u7576\u76f8\u95dc\u7684\u98a8\u96aa\u57fa\u56e0\u6bd4\u8f03\u591a\uff0c\u901a\u5e38\u4ee3\u8868\u9019\u500b\u904e\u654f\u75be\u75c5 (\u5982\uff1a\u6c23\u5598\u3001\u904e\u654f\u6027\u9f3b\u708e\u3001\u7570\u4f4d\u6027\u76ae\u819a\u708e) \u7684\u767c\u751f\u95be\u503c\u8f03\u4f4e\uff0c\u901a\u5e38\u6703\u8f03\u65e9\u3001\u8f03\u5bb9\u6613\u767c\u751f\uff1b\u53cd\u4e4b\uff0c\u82e5\u904e\u654f\u75be\u75c5\u7684\u76f8\u95dc\u57fa\u56e0\u8f03\u5c11 (\u5982\uff1a\u55dc\u9178\u6027\u6027\u98df\u9053\u708e)\uff0c\u5f80\u5f80\u4ee3\u8868\u9019\u500b\u75be\u75c5\u767c\u75c5\u95be\u503c\u9ad8\uff0c\u901a\u5e38\u6703\u8f03\u665a\u767c\u751f\uff0c\u4f46\u5f80\u5f80\u4e5f\u4ee3\u8868\u9019\u500b\u75be\u75c5\u7684\u56b4\u91cd\u5ea6\u8f03\u9ad8\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u6b64\u5916\uff0c\u5927\u90e8\u5206\u904e\u654f\u76f8\u95dc\u57fa\u56e0\u4f4d\u65bc\u57fa\u56e0\u9ad4\u975e\u7de8\u78bc\u5340\uff0c\u5927\u591a\u662f\u900f\u904e\u8abf\u63a7\u57fa\u56e0\u8868\u73fe\u767c\u63ee\u4f5c\u7528\uff0c\u9019\u4fbf\u4f50\u8b49<strong>\u5f8c\u5929\u7684\u5f71\u97ff\u662f\u8db3\u4ee5\u5927\u65bc\u5148\u5929\u57fa\u56e0\u7684<\/strong>\uff0c\u5f8c\u5929\u56e0\u5b50\uff08\u5982\uff1a\u7a7a\u6c61\u3001\u98f2\u98df\u3001\u8178\u9053\u83cc\u76f8\u3001\u751f\u6d3b\u58d3\u529b&#8230;\u7b49\u7b49\uff09\u626e\u6f14\u4e86\u300c\u89f8\u767c\u958b\u95dc\u300d\u7684\u89d2\u8272\uff0c\u4e26\u900f\u904e\u8868\u89c0\u907a\u50b3\uff08Epigenetics\uff09\u9014\u5f91\uff0c\u52d5\u614b\u6539\u8b8a\u57fa\u56e0\u7684\u8868\u73fe\u91cf\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u7d9c\u5408\u4e0a\u8ff0\uff0cDr. L \u60f3\u544a\u8a34\u5927\u5bb6\uff0c<strong>\u57fa\u56e0\u4e0d\u4ee3\u8868\u4e00\u5207\uff0c\u5c0d\u65bc\u904e\u654f\u75be\u75c5\uff0c\u66f4\u7d55\u975e\u662f\u57fa\u56e0\u6c7a\u5b9a\u8981\u4e00\u8f29\u5b50\u60a3\u75c5\uff1b\u66f4\u591a\u7684\u5f8c\u5929\u56e0\u7d20\u8db3\u4ee5\u6539\u8b8a\u5148\u5929\u57fa\u56e0\u7684\u8868\u73fe\u65b9\u5f0f\uff0c\u9032\u800c\u6709\u6a5f\u6703\u8b93\u904e\u654f\u6700\u7d42\u9054\u5230\u75ca\u7652\u7684\u7d50\u679c<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501\u2501<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udcda References<\/p>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li>Lawson, L. P., Parameswaran, S., Panganiban, R. A., Constantine, G. M., Weirauch, M. T., &amp; Kottyan, L. C. (2025). Update on the genetics of allergic diseases. <em>Journal of Allergy and Clinical Immunology<\/em>, <em>155<\/em>(6), 1738\u20131752. <a href=\"https:\/\/doi.org\/10.1016\/j.jaci.2025.03.012\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jaci.2025.03.012<\/a><\/li>\n<\/ol>\n\n\n\n<p 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