Don’t come, the king of cancer!

In past articles, the author has repeatedly mentioned that excessive intake of "sugar" will cause many different health hazards, and today I will discuss another level of health effects.

Pancreatic Cancer vs. Sugar

Why is pancreatic cancer specifically discussed? becausePancreatic cancerThere is another sensational nickname:

!!!【The King of Cancer】!!!

In clinical work, whenever the medical staff hears this diagnosis, they still inevitably worries about it. What are they worrying about? The prognosis of this kind of cancer is really bad... Pancreatic cancer is not easy to be detected. It is usually at an advanced stage when it is discovered. From the beginning of diagnosis, the five-year survival rate for the second stage and above is less than 30%, and the third stage is even as low as only 10%. You can imagine why Pancreatic cancer is called the king of cancer.

We know from the literature in the past that the rise and fall of blood sugar is directly related to the amount of sugar we consume, and further studies have found that:Whether in pre-diabetic or diabetic patients, hyperglycemia is highly correlated with pancreatic cancer;andCompared with other cancers, the prevalence of diabetes is significantly higher among patients with pancreatic cancer.

Therefore, the research teams from Taiwan’s Academia Sinica, National Taiwan University, and China Medical University have further explored the potential pathogenic mechanism of pancreatic cancer. The results of the team were finally published in the journal Cell Metabolism: "High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells"

In this study, the team analyzed the pathological tissues of 25 pancreatic cancer patients and found that only pancreatic cancer patients with diabetes had KRAS gene mutations in their pancreatic cells, while other organs and tissues did not have KRAS gene mutations. In addition, there were no diabetes patients. All organs of patients with pancreatic cancer do not have this gene mutation.

(Note: KRAS is an important gene for cell regulation. It acts like a "switch" in the signal transduction pathways of tumor cell growth, proliferation, and angiogenesis, thereby affecting the growth and spread of tumors)

Further research by the team found:

onlySugar causes genetic mutations in pancreatic cells.
High-sugar and high-fat dietIt will only affect the pancreas, not the canceration of other organs.

In terms of pathogenic mechanism, it is organized as follows:
The body’s intake of glucose produces nucleotides called dNTPs, ifExcessive intake of glucose will increase the glycation of protein in pancreatic cells, which will reduce the activity of enzymes that regulate the amount of dNTPs, Make the production of dNTP in the cell insufficient, and make pancreatic cells make mistakes due to insufficient raw materials during the genome replication and repair process, and finally cause gene mutation and cell canceration.

Therefore, if you want to avoid the cancer king, please start todayReduce sugar intake, Uphold "Eat less refined sugars and moderate starchy foods"The principle of maintaining a good blood sugar balance in your body!"