So this is the real truth about irritable bowel syndrome?!

Irritable Bowel Syndrome (IBS) In recent years, this disease has begun to receive a lot of attention. Chronic patients often experience intestinal symptoms such as bloating, borborygmus, diarrhea, abdominal pain, and mucus in the stool. They may also experience non-intestinal symptoms (such as headache, dizziness, fatigue, etc.) from time to time.

Irritable bowel syndrome (IBS) is a gut-brain interaction disorder. Patients with more than 801 TP3T report symptoms related to food intake, but traditional IgE-mediated food allergy tests have an extremely low positive rate in IBS patients, failing to explain their food intolerance symptoms. Considering that gut symptoms are not as easily observable and assessable as runny nose or eczema, how exactly does IBS occur?

In 2025, it was newly published in an international journal. Applied Sciences ofpaper: "Is IBS a Food Allergy? Confocal Laser Endomicroscopy Findings in Patients with IBS: A Narrative Review
The book provides further direct evidence and explanation regarding the occurrence of irritable bowel syndrome.

Confocal laser endomicroscopy (CLE) can provide real-time high-resolution tissue images during colonoscopy, allowing for real-time observation of the intestinal mucosa's response to specific food antigens. Therefore, the research team reviewed the literature, selected and included 74 studies that used endoscopy to explore the intestinal barrier in IBS patients or individuals with allergies, and summarized the research results. Dr. L will list the key points below.

▌Pathological Mechanism: Non-IgE-mediated "Local Gut Hypersensitivity"

1. Some IBS patients do not have systemic IgE allergy, but rather have underlying IgE deficiency.Local intestinal mucosal immune activation.

2. Certain IBS patients may experience [symptoms] after exposure to food antigens.Fluorescein leakageversusCell sheddingAcute epithelial barrier dysfunction, etc.

3. Based on the CLE test results, a customized food elimination diet is implemented, exceeding [a certain threshold]. 70% The patients' symptoms improved significantly.

In addition, it was published in an international journal in 2019. Gastroenterology & Hepatology The article was written by Professor Nicholas J. Talley after an interview.paperThe content explores the epidemiological and immunological links between atopic diseases (such as asthma and eczema) and irritable bowel syndrome. Dr. L will also list the key points below.

1. Food allergies mediated by traditional IgE are not common in irritable bowel syndrome (IBS), and standard allergen tests (such as skin patches, RAST, IgG detection panels) have no diagnostic value.

2. Food antigens (such as wheat protein) can trigger acute mucosal pathological reactions mediated by non-IgE, confirming that some cases of irritable bowel syndrome (IBS) are driven by an "atypical food allergy" mechanism.

3. In patients with irritable bowel syndrome (IBS), lesions are often observed in the duodenal or small intestinal mucosa.Increased intestinal permeabilityversustissue eosinophil/mast cell proliferation and activation.

4. Epidemiological data show that atopic diseases such as asthma, eczema, and urticaria are highly correlated with irritable bowel syndrome (IBS) and functional dyspepsia.

As can be seen from the above research, the intestinal symptoms of irritable bowel syndrome (IBS) are highly similar to those of common allergies. Dr. L also believes that...Irritable bowel syndrome is part of a broader category of allergies.However, irritable bowel syndrome (IBS) cannot be effectively confirmed by traditional IgE-mediated food allergy tests; furthermore, considering the high correlation between allergic diseases such as asthma, eczema, and urticaria and IBS, it serves as a further reminder that...Please do not ignore the disease signals of your intestinal system. It is recommended to present these signals to your clinician during the evaluation process..

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📚 References

1. Pavan, F., Costantino, A., Tontini, GE, Elli, L., Siragusa, N., Lasagni, G., Dubini, M., Scricciolo, A., & Vecchi, M. (2025). Is IBS a Food Allergy? Confocal Laser Endomicroscopy Findings in Patients with IBS: A Narrative Review. Applied Sciences, 15(7), 3717. https://doi.org/10.3390/app15073717
2. Talley, NJ (2019). Allergies and Irritable Bowel Syndrome. Gastroenterology & Hepatology, 15(11), 619–621. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883730/

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